Herbal Remedies Should Be Used With Caution

(from the April 99, Newsletter)

An increasing number of people are using herbal remedies for a variety of medical problems such as arthritis, depression, diabetes and menstrual irregularity. They do so without informing their family doctors or other health care providers, because they assume that these products are safe since they are promoted by the suppliers as being "natural" and are commonly referred to as "health food". In actual fact, many of these herbal remedies can interact with drugs that were prescribed by the family physician or other health care provider, resulting in very serious health consequences. For example. feverfew, garlic, Ginkgo, ginger and ginseng may alter an individual's ability to stop bleeding when cut and they should therefore not be used at the same time that a person is taking an anticlotting drug like coumadin. As well, Kava can result in coma when used together with a sedative like alprazolam. A summary of drug-herb interactions of commonly used herbal remedies is provided in the table below.

Another concern about the use of herbal remedies is the fact that one is often unsure of just how much of the herb one is actually taking. Many herbs are sold as teas, foods and food supplements. Since they are not sold as drugs, no proof of efficacy or warning about possible side effects is required. When a drug is prescribed, its dosage and quality are usually assured, because there is a mechanism in place at the federal level to regulate the introduction of new drugs in the marketplace. Unfortunately, there is no such standardization or quality control in place for herbal preparations. Patients must therefore exercise caution when they decide to use a herbal remedy.

The purpose of this article is not to discourage you from using herbal remedies. Instead, it is intended to increase your awareness of the fact that herbal remedies can be harmful if used inappropriately and if they interact with prescription drugs. Given the fact that the potential exists for serious drug-herb interactions to occur, it is very important that you inform your family physician of any herbal remedies that you are currently taking. This will enable your health care provider to examine the possibility of an interaction occurring between the herb that you are taking and the medications that were prescribed for your medical condition(e.g., diabetes). If you are not currently using a herbal remedy but intend to do so in the near future, you should discuss this with your family doctor before you actually begin to use the herb. Remember that an ounce of prevention is worth a pound of cure.

Dr. Roger Johnson Community Medical Officer of Health

Summary of Drugs-Herb Interactions of Commonly Used Herbs

 Drug Purpose of Drug Herbal Remedy

Drug-Herb

Interaction

Recommended

Action

 Alprazolam Treat anxiety and panick attacks Kava

Excessive

sedation

Avoid taking kava and alprazolam together.

 Corticosteroids

and

Cyclosporine

 Combat inflammation and help prevent rejection of transplant organs by suppressing the immune system

 Echinacea,

Astragalus

Licorice

Alfalfa Sprouts

Vitaman E

Zink

These herbs might stimulate the immune system and thereby counteract the effect of these drugs Avoid use of these herbal remedies if you are already taking corticosteroids, cyclosporine or other drugs that will suppress your immune system
 Digoxin Treat congestive heart failure and to control irregular heartbeats
 Hawthorn May increase the effects of digoxin
 Licorice  May cause low potassium in the blood and thereby increase teh effects of digoxin
 Plantain  May contain foxglove, which will increase digoxin blood level.
 Siberian ginseng and Kyushin  May interfere with digoxin level in the blood.
 Uzara root  May increase the effects of digoxin on the heart.
 Avoid taking these herbal remedies if you are already taking digoxin.

 Phenelzine

(and other MAO

inhibitors)

 Used to treat depression
 Ginseng, Yhimibine, Ephedra  Combined use of these herbal remedies and these drugs may result in insomnia, headache and tremulousness.

 St.John Wort

Licorice

 May increase the effect of MAO inhibitors like phenelzine
 Do not use these herbal remedies together with phenelzine and other MAO inhibitors.
 Phenobarbital Used to treat seizure disorders

 Thujone-containing herbs, such as Wormwood Sage;

Gamolenic acid-containing herbs, i.e. Evening primrose oile, Borage

 May facilitate seizure activity and thereby increase the dosage requirements for phenobarbital  Do not use these herbal remedies together with phenobarbital.
 Phenytoin Used to treat seizure disorders.

 Thujone-containing herbs such as Wormwood, Sage;

Gamolenic acid-containing herbs, i.e. Evening primrose oil, Borage;

 

Shankhapulshpi

 May facilitate seizure activity and thereby increase the dosage requirements for phenytoin.;

 

May decrease the effectiveness of pheytoin

 Do not use these herbal remedies together with phenytoin.
 Spironolactone  Used to treat fluid retention and gongestive heart failure.  Licorice  May offset the effects of spironolactone by causing sodium retention and increased blood pressure.  Do not use these herbal remedies together with spironolactone.
 Warfarin (Coumadin)  Used to treat clots and to prevent clots from developing.
 Garlic, Ginger, Gingko, Feverfew  May increase the effect of Warfarin
 Ginseng  May decrease the effectiveness of warfarin
 Avoid concomitant use of these herbal remedies with warfarin.

 Diuretics (i.e. furosmide and hydrochloro-

thizide)

 Used to treat blood pressure and congestive heart failure.
 Dandelion Uva-ursi  Increase sodium level in the blood, which may increase teh effectiveness of the diuretics
 Gossypol

 May worsen teh low level of potassium in the blood caused by diuretics like furosemide and hydrocholoro-

thiamizide.

 Avoid taking these herbal remedies if you are already faking a "water pill" for your high blood pressure.
 Hypoglycemics (i.e. Glyburide, chlorpropamide)  Used to lower blood sugar in diabetes
 Chromium  May decrease insulin requirements
 Karela  Has been shown to decrease dosage requirements for chlorpropamide.
 Do not take these harbal remedies if you are taking medication for diabetes.
 Iron

 Used to treat iron-

deficiency anemia.

 Chamomile Feverfew,

St.John Wort.

 May interact with iron, hence inhibiting iron absorption.  You should tell your doctor that you are taking these remedies so that your iron level in the blood can be monitored closely. You may need to stop taking these hergal remedies if you are not responding well to iron replacement therapy.

 Levothyroxine

(Eltroxin, Synthroid)

 Used to treat people with inactive thyroid glands.  Horseradish Kelp  May suppress thyroid function  You should not use these herbal remedies if you are taking levothyroxine.
 Nonsteroridal anti-inflammatory drugs.  Used to treat inflammation and pain.  Gossypol Uva-ursi  Additive GI irritation may be encountered with these herbs, which are known to irritate the GI tract.  Do not use these herbal remedies together with non-steroidal anti-inflammatory medications

(Adapted from: Miller LG, Herbal Medicines. Arch Intern Med 1998; 158; 2200-2211)


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