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Herbal Remedies Should Be Used With Caution (from the April 99, Newsletter) An increasing number of people are using herbal remedies for a variety of medical problems such as arthritis, depression, diabetes and menstrual irregularity. They do so without informing their family doctors or other health care providers, because they assume that these products are safe since they are promoted by the suppliers as being "natural" and are commonly referred to as "health food". In actual fact, many of these herbal remedies can interact with drugs that were prescribed by the family physician or other health care provider, resulting in very serious health consequences. For example. feverfew, garlic, Ginkgo, ginger and ginseng may alter an individual's ability to stop bleeding when cut and they should therefore not be used at the same time that a person is taking an anticlotting drug like coumadin. As well, Kava can result in coma when used together with a sedative like alprazolam. A summary of drug-herb interactions of commonly used herbal remedies is provided in the table below. Another concern about the use of herbal remedies is the fact that one is often unsure of just how much of the herb one is actually taking. Many herbs are sold as teas, foods and food supplements. Since they are not sold as drugs, no proof of efficacy or warning about possible side effects is required. When a drug is prescribed, its dosage and quality are usually assured, because there is a mechanism in place at the federal level to regulate the introduction of new drugs in the marketplace. Unfortunately, there is no such standardization or quality control in place for herbal preparations. Patients must therefore exercise caution when they decide to use a herbal remedy. The purpose of this article is not to discourage you from using herbal remedies. Instead, it is intended to increase your awareness of the fact that herbal remedies can be harmful if used inappropriately and if they interact with prescription drugs. Given the fact that the potential exists for serious drug-herb interactions to occur, it is very important that you inform your family physician of any herbal remedies that you are currently taking. This will enable your health care provider to examine the possibility of an interaction occurring between the herb that you are taking and the medications that were prescribed for your medical condition(e.g., diabetes). If you are not currently using a herbal remedy but intend to do so in the near future, you should discuss this with your family doctor before you actually begin to use the herb. Remember that an ounce of prevention is worth a pound of cure. Dr. Roger Johnson Community Medical Officer of Health |
| Drug | Purpose of Drug | Herbal Remedy | Drug-Herb Interaction |
Recommended Action | ||||||||||
| Alprazolam | Treat anxiety and panick attacks | Kava | Excessive sedation |
Avoid taking kava and alprazolam together. | ||||||||||
Corticosteroids and Cyclosporine |
Combat inflammation and help prevent rejection of transplant organs by suppressing the immune system | Echinacea, Astragalus Licorice Alfalfa Sprouts Vitaman E Zink |
These herbs might stimulate the immune system and thereby counteract the effect of these drugs | Avoid use of these herbal remedies if you are already taking corticosteroids, cyclosporine or other drugs that will suppress your immune system | ||||||||||
| Digoxin | Treat congestive heart failure and to control irregular heartbeats |
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Avoid taking these herbal remedies if you are already taking digoxin. | |||||||||||
Phenelzine (and other MAO inhibitors) |
Used to treat depression |
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Do not use these herbal remedies together with phenelzine and other MAO inhibitors. | |||||||||||
| Phenobarbital | Used to treat seizure disorders | Thujone-containing herbs, such as Wormwood Sage; Gamolenic acid-containing herbs, i.e. Evening primrose oile, Borage |
May facilitate seizure activity and thereby increase the dosage requirements for phenobarbital | Do not use these herbal remedies together with phenobarbital. | ||||||||||
| Phenytoin | Used to treat seizure disorders. | Thujone-containing herbs such as Wormwood, Sage; Gamolenic acid-containing herbs, i.e. Evening primrose oil, Borage;
Shankhapulshpi |
May facilitate seizure activity and thereby increase the dosage requirements for phenytoin.;
May decrease the effectiveness of pheytoin |
Do not use these herbal remedies together with phenytoin. | ||||||||||
| Spironolactone | Used to treat fluid retention and gongestive heart failure. | Licorice | May offset the effects of spironolactone by causing sodium retention and increased blood pressure. | Do not use these herbal remedies together with spironolactone. | ||||||||||
| Warfarin (Coumadin) | Used to treat clots and to prevent clots from developing. |
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Avoid concomitant use of these herbal remedies with warfarin. | |||||||||||
Diuretics (i.e. furosmide and hydrochloro- thizide) |
Used to treat blood pressure and congestive heart failure. |
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Avoid taking these herbal remedies if you are already faking a "water pill" for your high blood pressure. | |||||||||||
| Hypoglycemics (i.e. Glyburide, chlorpropamide) | Used to lower blood sugar in diabetes |
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Do not take these harbal remedies if you are taking medication for diabetes. | |||||||||||
| Iron | Used to treat iron- deficiency anemia. |
Chamomile Feverfew, St.John Wort. |
May interact with iron, hence inhibiting iron absorption. | You should tell your doctor that you are taking these remedies so that your iron level in the blood can be monitored closely. You may need to stop taking these hergal remedies if you are not responding well to iron replacement therapy. | ||||||||||
Levothyroxine (Eltroxin, Synthroid) |
Used to treat people with inactive thyroid glands. | Horseradish Kelp | May suppress thyroid function | You should not use these herbal remedies if you are taking levothyroxine. | ||||||||||
| Nonsteroridal anti-inflammatory drugs. | Used to treat inflammation and pain. | Gossypol Uva-ursi | Additive GI irritation may be encountered with these herbs, which are known to irritate the GI tract. | Do not use these herbal remedies together with non-steroidal anti-inflammatory medications | ||||||||||
(Adapted from: Miller LG, Herbal Medicines. Arch Intern Med 1998; 158; 2200-2211)